Effects of prenatal exposure to toluene on postnatal development and behavior in rats

¹Department of Chemical Working Environments, National Institute of Occupational Health, Copenhagen, Denmark. ksh@ami.dk

|July 1, 1999

Abstract:

Development and neurobehavioral effects of prenatal exposure to toluene (CAS 108-88-3) were studied after exposing pregnant rats (Mol:WIST) to 1800 ppm of the solvent for 6 h daily on days 7-20 of gestation. Body weights of exposed offspring were lower until day 10 after parturition. Neurobehavioral evaluation of the pups revealed no effects on motor function (rotarod), activity level (open field), acoustic startle, and prepulse inhibition. Measurements of hearing function using auditory brain stem response revealed small effects in male-exposed offspring. Performance in a Morris water maze during initial learning gave some indications of impaired cognitive functions, which was confirmed during further testing, especially in reversal and new learning. Effects on cognitive functions seemed most marked in female offspring.

Related Experiment Videos

Effects of prenatal exposure to toluene on postnatal development and behavior in rats

Related Concept Videos

Body fat percentage in relation to semen characteristics, testicular volume, and reproductive hormones: a cross-sectional study.

Prenatal exposure to airborne polychlorinated biphenyl congeners and male reproductive health.

Dietary Inflammatory Index and Cross-Sectional Associations with Inflammation, Muscle Mass and Function in Healthy Old Adults.

Risk assessment of consumer spray products using in vitro lung surfactant function inhibition, exposure modelling and chemical analysis.

In vitro prediction of clinical signs of respiratory toxicity in rats following inhalation exposure.

EDC IMPACT: Reduced sperm counts in rats exposed to human relevant mixtures of endocrine disrupters.

Prenatal alcohol exposure and physical health outcomes in adolescence and adulthood: A systematic scoping review.

Neurobehavioral and metabolic consequences of embryonic triphenyl phosphate exposure across the lifespan in zebrafish.

A pilot autism case-control study of pesticides and plasticizers in shed baby teeth.

Effects of subchronic late-gestational nicotine exposure on postpartum maternal behavior in Wistar rats: An exploratory pilot study.

Periconceptional and prenatal tobacco exposure and early externalizing behavior: Developmental pathways through maternal distress and language delay.

Evidence of decreased neural efficiency supporting fluid reasoning abilities in children and adolescents chronically exposed to home radon.

CO and NO Detection by MN4@SWCNT in Background Gases: Multiscale DFT, Microkinetic, Boltzmann Transport Study.

Long non-coding RNA-gm33782 exacerbates acute kidney injury by upregulating the PA1-MLL3/MLL4 complex and promoting histone H3 lysine 4 monomethylation-dependent forkhead box O3 enhancer activation.

Prenatal exposure to a mixture of non-persistent endocrine-disrupting chemicals and attention and hyperactivity symptoms in children in the ECHO cohort.

High-Performance NH3 Sensing via Humidity-Mediated Proton Conduction in Electrospun Amorphous Sn/Ce-Containing Polymer Membranes.

Tire-Derived Microplastics as Chemically Complex Environmental Contaminants: Mechanistic Pathways, Exposure Gradients, and Implications for Environmental Health.

Railway curve squeal prediction using environmental variables.

Related Experiment Videos

Effects of prenatal exposure to toluene on postnatal development and behavior in rats

Abstract:

Related Concept Videos

Related Articles