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Novel derivatives of 3-(dipropylamino)chroman. Interactions with 5-HT1A and D2A receptors
P Caldirola1, R Chowdhury, L Unelius
1Organic Pharmaceutical Chemistry, Uppsala Biomedical Centre, Uppsala University, Sweden.
Bioorganic & Medicinal Chemistry Letters
|July 1, 1999
Abstract:
Novel 8-aryl and 8-aroyl substituted derivatives of 3-(dipropylamino)chroman are described. The compounds have been prepared by a palladium catalyzed reaction of iodoarenes and a stannylated derivative of [eta6-3-(dipropylamino)chroman]Cr(CO)3. Several of the compounds have high affinity for 5-HT1A receptors whereas the affinity for D2A receptors is lower, the 8-arylated derivatives being slightly more potent than the 8-aroylated analogues.