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Synthesis of 25-aminosterols, new antifungal agents
P Beuchet1, M Dherbomez, L Elkiel
1Laboratoire de Synthèse et Etude de Substances Naturelles à Activités Biologiques, Université de La Rochelle, France.
Bioorganic & Medicinal Chemistry Letters
|July 1, 1999
Abstract:
25-aminolanostenol 1 and 25-aminocholesterol 2 were hemisynthesized from natural sterols and tested in vitro against Candida albicans. The biological activity of compound 1 was rather weak, whereas 2 exhibited in vitro antifungal activity with MIC value of 4 microM.