Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Breast Cancer: High-Dose Therapy.

Subramanyan1, Kennedy

  • 1Johns Hopkins Oncology Center, Baltimore, Maryland, 21287, USA. ssubrama@welchlink.welch.jhu.edu

The Oncologist
|July 1, 1999
PubMed
Summary

High-dose chemotherapy with autologous stem cell rescue (HDC/ASCR) for breast cancer shows promise but may be influenced by selection bias in non-randomized studies. Clinical trials are essential to confirm its efficacy and determine its future role.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Case of a Man Who Died from Eating to Excess of the Bitter Almond.

The London medical and physical journal·2018
Same author

Observations on the Use of Nitrous Acid as a Substitute for Blisters.

Edinburgh medical and surgical journal·2018
Same author

Biofeedback for anismus: has placebo effect been overlooked?

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2013
Same author

Prevalence of faecal incontinence: obstetric and constipation-related risk factors; a population-based study.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2013
Same author

Case of an extensive Wound from the Bite of a Shark.

Medico-chirurgical transactions·2010
Same author

[1,1,2,2-]

Acta crystallographica. Section C, Crystal structure communications·2000

Area of Science:

  • Oncology
  • Hematology
  • Clinical Trials

Background:

  • Breast cancer is a leading indication for high-dose chemotherapy with autologous stem cell rescue (HDC/ASCR).
  • The use of HDC/ASCR has increased based on promising results from phase II studies.
  • Concerns exist regarding selection bias in non-randomized studies influencing outcomes.

Purpose of the Study:

  • To review early and phase II studies of HDC/ASCR for breast cancer, focusing on long-term follow-up.
  • To discuss the impact of selection bias on the outcomes of HDC/ASCR studies.
  • To evaluate randomized studies of HDC/ASCR and its current recommendation in clinical trials.

Main Methods:

  • Review of early dose-intensification studies and phase II HDC/ASCR trials for metastatic and high-risk breast cancer.
  • Analysis of studies with long-term follow-up to assess outcomes.
  • Examination of randomized controlled trials comparing HDC/ASCR to standard chemotherapy.

Main Results:

  • Phase II studies suggested higher response rates and survival times for HDC/ASCR compared to historical controls.
  • Evidence indicates significant selection bias in non-randomized phase II studies of HDC/ASCR.
  • Few randomized comparisons of HDC/ASCR versus standard chemotherapy are available.

Conclusions:

  • Currently, HDC/ASCR for breast cancer should only be administered within a clinical trial setting.
  • Further results from large randomized trials are needed to establish the definitive role of HDC/ASCR in breast cancer treatment.
  • The potential benefits of HDC/ASCR require validation through rigorous randomized studies to overcome selection bias concerns.

Related Experiment Videos