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Related Experiment Videos

Colonic carcinomas masquerading as Crohn's colitis.

T Rajalakshmi1, U Kini

  • 1Department of Pathology, St. John's Medical College, Bangalore, Karnataka, India.

Indian Journal of Cancer
|July 1, 1999
PubMed
Summary

Colonic carcinoma presenting with acute abdomen poses diagnostic challenges. This study found that a cobblestone appearance in resected segments, mimicking Crohn's disease, indicated poor prognosis in advanced colon cancer.

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Area of Science:

  • Gastroenterology
  • Surgical Pathology
  • Oncology

Background:

  • Colonic carcinomas presenting as acute abdomen create significant diagnostic and therapeutic challenges for surgeons and pathologists.
  • Acute intestinal obstruction is a critical presentation of colon cancer, often associated with poor outcomes.

Purpose of the Study:

  • To investigate the pathological features of colonic carcinomas presenting with acute intestinal obstruction.
  • To analyze the prognostic significance of observed pathological findings in these challenging cases.

Main Methods:

  • Retrospective analysis of 92 cases of carcinoma of the colon.
  • Detailed examination of 4 cases presenting with acute intestinal obstruction, including gross and microscopic pathological assessment.

Main Results:

  • Three out of four patients with colonic carcinoma presenting with acute intestinal obstruction experienced a complicated postoperative course and succumbed.
  • Gross examination of resected segments revealed a cobblestone appearance, suggestive of Crohn's disease.
  • Microscopic examination showed ischemic changes at the stricture site with features of poorly differentiated adenocarcinoma.

Conclusions:

  • Colonic carcinomas presenting with acute intestinal obstruction, especially those with a cobblestone appearance, have a grave prognosis.
  • The pathological findings highlight the complexity of diagnosing and managing colon cancer in emergency settings.

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