Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Higher rates of pressure decrease in inflamed compared with noninflamed middle ears.

C M Alper1, W J Doyle, J T Seroky

  • 1Department of Otolaryngology, Children's Hospital of Pittsburgh and the University of Pittsburgh School of Medicine, Pennsylvania, USA.

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
|July 2, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Relationship between surface area and volume of the mastoid air cell system in adult humans.

The Journal of laryngology and otology·2011
Same author

Effects of chronic peanut consumption on energy balance and hedonics.

International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity·2002
Same author

Effect of experimental influenza A infection on systemic immune and inflammatory parameters in allergic and nonallergic adult subjects.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2002
Same author

Urinary histamine metabolite elevations during experimental influenza infection.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2001
Same author

Effect of intranasal challenge with interleukin-6 on upper airway symptomatology and physiology in allergic and nonallergic patients.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2001
Same author

Abnormal middle ear pressures during experimental influenza A virus infection--role of Eustachian tube function.

Auris, nasus, larynx·2000
Same journal

Gender-Affirming Care in Otolaryngology: A State of the Art Review.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2026
Same journal

Caffeine Consumption and Rhinologic Symptom Severity.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2026
Same journal

Ethical Considerations in Using the Pernkopf Atlas in Otolaryngology Education Ethics in Practice: Point-Counterpoint.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2026
Same journal

Preoperative Neutrophil-to-Lymphocyte Ratio Predicts Recurrence in HPV-Associated Oropharyngeal Cancer After Transoral Robotic Surgery.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2026
Same journal

PEAK-II Trach: A Multi-Institutional Quality Improvement/Simulation Study Assessing Pediatric Emergency Readiness.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2026
Same journal

Clinical Features, Treatment, and Outcomes for Oropharyngeal Adenoid Cystic Carcinoma: A Systematic Review.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2026
See all related articles

Middle ear inflation shows limited efficacy for otitis media with effusion. Nitrogen (N2) inflation in rhesus monkeys demonstrated faster pressure decrease and lower terminal pressures in inflamed ears, but sequential inflations showed dampened effects.

Area of Science:

  • Otolaryngology
  • Medical Physiology
  • Biomedical Engineering

Background:

  • Otitis media with effusion (OME) is a common condition, often treated with middle ear inflation.
  • Previous studies in humans indicate rapid pressure decrease after air inflation for negative middle ear pressure.
  • Renewed clinical interest in middle ear inflation necessitates further investigation into its efficacy.

Purpose of the Study:

  • To investigate the efficacy of middle ear inflation using air versus nitrogen (N2) in a primate model of otitis media with effusion.
  • To compare pressure dynamics following inflation in inflamed versus healthy middle ears.
  • To assess the impact of sequential inflations on middle ear pressure stabilization.

Main Methods:

  • Unilateral otitis media with effusion was induced in anesthetized rhesus monkeys.

Related Experiment Videos

  • Middle ears were inflated with either air or N2 at various time points.
  • Middle ear pressures were continuously recorded using tympanometry until stabilization or recovery from anesthesia.

    • Main Results:

    • Air inflation results mirrored human studies, showing rapid pressure decrease in negative middle ear pressure.
    • Nitrogen (N2) inflation led to a significantly faster pressure decrease and lower terminal pressures in inflamed ears compared to control ears.
    • Sequential N2 inflations demonstrated a dampened rate of pressure decrease and reduced magnitude of pressure drop.

    Conclusions:

    • Middle ear inflation, particularly with N2, shows potential but limited efficacy in managing negative middle ear pressure associated with OME.
    • The observed dampening effect with sequential N2 inflations suggests a need for optimized inflation protocols.
    • Findings have significant clinical implications for the therapeutic application of middle ear inflation in treating otitis media with effusion.