Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multilocus approach to cardiovascular risk.

C Pallaud1, M Maurice, S Cheng

  • 1INSERM U525, Centre de Médicine Préventive, Nancy, France.

Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum
|July 2, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nutritional Assessment in Patients with Early-Onset Autosomal Dominant Alzheimer's Disease Due to PSEN1- E280A Genetic Variant: A Cross-Sectional Study.

JAR life·2023
Same author

<i>APOE3</i> Christchurch modulates tau phosphorylation and β-catenin/Wnt/Cadherin signaling in induced pluripotent stem cell-derived cerebral organoids from Alzheimer's cases.

bioRxiv : the preprint server for biology·2023
Same author

An audit of dementia education and training in UK health and social care: a comparison with national benchmark standards.

BMC health services research·2019
Same author

Assessment of Health Inequalities Among Older People Using the EPICES Score: A Composite Index of Social Deprivation.

The Journal of frailty & aging·2017
Same author

[Therapeutic plasma exchange for the treatment of hypertriglyceridemia-induced pancreatitis : A case report].

Medizinische Klinik, Intensivmedizin und Notfallmedizin·2016
Same author

Performance of cognitive tests, individually and combined, for the detection of cognitive disorders amongst community-dwelling elderly people with memory complaints: the EVATEM study.

European journal of neurology·2015

Genetic factors significantly influence lipid levels, with apolipoprotein E and apolipoprotein B gene polymorphisms impacting cholesterol and triglyceride variability. A multilocus approach is key to understanding cardiovascular risk.

Area of Science:

  • Genetics
  • Cardiovascular Disease Research
  • Biochemistry

Background:

  • Familial studies indicate shared genetic and environmental factors influence lipid parameter variability.
  • Previous research has identified specific gene polymorphisms associated with lipid levels.

Purpose of the Study:

  • To investigate the impact of specific gene polymorphisms on lipid metabolism parameters.
  • To explore the combined effects of multiple gene polymorphisms on lipid variability.
  • To establish a multilocus approach for assessing genetic susceptibility to cardiovascular risk.

Main Methods:

  • Analysis of 119 families to assess the role of apolipoprotein E (apo E), apolipoprotein A-IV, apolipoprotein B, and lipoprotein lipase (LPL) gene polymorphisms.
  • Utilized a prototype assay for genotyping 35 polymorphic sites across 15 candidate genes in 416 individuals from the Stanislas Cohort.

Related Experiment Videos

  • Employed multiplex polymerase chain reactions and hybridization to immobilized oligonucleotide probes.

    • Main Results:

    • Apolipoprotein E (apo E) polymorphism affects total cholesterol, LDL-Cholesterol, apo E, and apo B levels.
    • Apolipoprotein B gene is associated with variability in total cholesterol, HDL-Cholesterol, LDL-Cholesterol, triglycerides, and apo B levels.
    • Lipoprotein lipase (LPL) gene accounts for 6.5% of triglyceride variability; combined apo E and LPL polymorphisms influence lipid parameters.

    Conclusions:

    • Polymorphisms in apo E and apo B genes are significant contributors to lipid level variability.
    • A multilocus genetic approach is essential for a comprehensive understanding of lipid metabolism and cardiovascular risk.
    • The ongoing multiplex assay in the Stanislas Cohort will enhance understanding of inter-individual lipid variability and genetic susceptibility to cardiovascular disease.