Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neuromodulation, development and synaptic plasticity.

R C Foehring1, N M Lorenzon

  • 1Department of Anatomy & Neurobiology, University of Tennessee, Memphis 38163, USA.

Canadian Journal of Experimental Psychology = Revue Canadienne De Psychologie Experimentale
|July 2, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Contributions of Kv7-mediated potassium current to sub- and suprathreshold responses of rat layer II/III neocortical pyramidal neurons.

Journal of neurophysiology·2011
Same author

Endogenous calcium buffering capacity of substantia nigral dopamine neurons.

Journal of neurophysiology·2009
Same author

Kv2 subunits underlie slowly inactivating potassium current in rat neocortical pyramidal neurons.

The Journal of physiology·2007
Same author

Functional roles of Kv1 channels in neocortical pyramidal neurons.

Journal of neurophysiology·2007
Same author

Expression and biophysical properties of Kv1 channels in supragranular neocortical pyramidal neurones.

The Journal of physiology·2005
Same author

Effects of temperature on calcium transients and Ca2+-dependent afterhyperpolarizations in neocortical pyramidal neurons.

Journal of neurophysiology·2004

Neuromodulators regulate brain plasticity by altering ion channel function during development and in adult synaptic potentiation (LTP) and depression (LTD). These changes impact neuronal activity and brain development.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Synaptic Plasticity

Background:

  • Use-dependent synaptic plasticity is crucial for brain development and function.
  • Neuromodulators like norepinephrine, serotonin, and acetylcholine influence plasticity.
  • Ion channels are key targets for neuromodulatory effects on neuronal excitability.

Purpose of the Study:

  • To explore parallels between developmental plasticity and long-term potentiation/depression (LTP/LTD) in neocortical synapses.
  • To investigate the role of neuromodulators in regulating these plasticity mechanisms.
  • To examine how ion channel modulation by neuromodulators affects neuronal firing.

Main Methods:

  • Comparative analysis of developmental plasticity and LTP/LTD mechanisms.

Related Experiment Videos

  • Review of studies on neuromodulator effects on ion channels.
  • Examination of changes in ion channel expression during cortical development.

    • Main Results:

    • Parallels exist in the mechanisms of developmental plasticity and LTP/LTD.
    • Neuromodulators significantly influence both developmental plasticity and LTP/LTD.
    • Modulation of voltage-gated Ca2+ and Ca2+-dependent K+ channels by neuromodulators alters pyramidal cell firing.
    • Ion channel composition in rat cortex changes during development, affecting neuromodulatory targets.

    Conclusions:

    • Neuromodulators and ion channel dynamics are critical regulators of neocortical plasticity across development.
    • Understanding these interactions provides insights into brain development and disorders.
    • Changes in ion channel expression during ontogeny shape the impact of neuromodulation on neuronal activity.