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Angiogenesis of the endometrium
1Department of Obstetrics and Gynecology, State University of New York at Brooklyn, USA.
Obstetrics and Gynecology
|July 2, 1999
Summary
Angiogenesis, the formation of new blood vessels, is crucial in the endometrium during the menstrual cycle and in various endometrial diseases. Understanding these patterns may lead to better anti-angiogenic therapies.
Area of Science:
- Reproductive biology
- Gynecologic pathology
- Vascular biology
Background:
- Endometrial angiogenesis is a dynamic process.
- It plays a role in normal cyclic regeneration and various pathological conditions.
Purpose of the Study:
- To review current data on endometrial angiogenesis.
- To cover normal cycles and benign/neoplastic endometrial diseases.
Main Methods:
- Computerized literature search (MEDLINE, Current Contents, Index Medicus).
- Review of studies on human and animal models.
- Inclusion of data from January 1966 to October 1998.
Main Results:
- Angiogenesis is vital for cyclic endometria and diseases like dysfunctional uterine bleeding, endometriosis, and endometrial carcinoma.
- It's also relevant in response to hormonal treatment and with intrauterine devices.
Conclusions:
- Specific angiogenic patterns in diseases could enhance anti-angiogenic drug therapies.
- Future research may improve treatment for benign and neoplastic endometrial conditions.