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Related Experiment Videos

Nimodipine and perfusion changes after stroke.

B Infeld1, S M Davis, G A Donnan

  • 1Department of Neurology, Royal Melbourne Hospital, Australia.

Stroke
|July 2, 1999
PubMed
Summary
This summary is machine-generated.

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Oral nimodipine enhanced reperfusion in acute stroke patients within 12 hours, but this effect was nonnutritional and did not improve clinical outcomes. Further research is needed to confirm nimodipine

Area of Science:

  • Neurology
  • Radiology
  • Pharmacology

Background:

  • Previous meta-analyses suggest oral nimodipine benefits acute stroke if started within 12 hours.
  • This study investigates nimodipine's impact on reperfusion and its relationship with outcomes in acute stroke.

Purpose of the Study:

  • To evaluate the effect of oral nimodipine on reperfusion in acute ischemic stroke.
  • To determine the association between reperfusion and clinical outcomes.

Main Methods:

  • Randomized, double-blind, placebo-controlled trial of 50 acute middle cerebral artery infarction patients.
  • Oral nimodipine (30 mg every 6 hours) or placebo for 2 weeks.
  • Cerebral blood flow assessed via SPECT, hypoperfusion measured volumetrically, and neurological/functional outcomes evaluated.

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Main Results:

  • Nimodipine group showed early reperfusion (P=0.01), but it was not sustained.
  • Nonnutritional reperfusion in nimodipine patients correlated with adverse neurological and functional outcomes.
  • No significant difference in overall clinical outcome between nimodipine and placebo groups.

Conclusions:

  • Oral nimodipine within 12 hours increases acute reperfusion, though largely nonnutritional.
  • The clinical efficacy of nimodipine in acute ischemic stroke requires larger studies with shorter treatment delays.