[Genetical aspects in cerebrovascular disease]
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Updated: Oct 20, 2026

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Published on: May 17, 2024
1Departamento de Neurología, Hospital J.M. Ramos Mejía, Argentina. gsaposnik@yahoo.com
Introduction:
Stroke is a pathophysiological heterogeneous syndrome with numerous genetic influences.
Development:
Previous populational studies had demonstrated the familial correlation. The parental history of stroke has been associated with stroke in the descendant with a significant relative risk of 2. A study of mono- and dizygotic twins found a fivefold risk of stroke among monozygotic compared with dizygotic. Other modifiable and non-modifiable risk factors are involve in cerebrovascular disease. Recently, the gene that codifies the angiotensin converting enzyme has been determine. An insertion/deletion polymorphism of was associated with increased levels of angiotensin converting enzyme. ApoE4 and high levels of homocysteine has been reported as a risk factors for cerebral infarction. Apoptotic mechanisms have recently been discovered in rats models of ischemia. Caspases inhibitors have shown a reduction of 40% in the cerebral infarction area.
Conclusion:
The purpose of this work is to analyze the genetic factors that constitute an influence in stroke.
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