[Molecular structure of renin-angiotensin-aldosterone system]

The application of novel investigative techniques has demonstrated that the RAA system is one of the major regulators of blood pressure and fluid and electrolyte homeostasis. There is evidence that local RAA systems exist. In this paper we have presented molecular bases of RAA system structure-genomic analysis, tissue distribution, regulation and pharmacological implications. We have payed attention to genomic linkage of the angiotensynogen gene with predisposition to the essential hypertension at human and to possibility of hormones influence at expression this gene.