Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Aortic dissection in Marfan's syndrome.

S Westaby1

  • 1The Oxford Heart Centre, John Radcliffe Hospital, England.

The Annals of Thoracic Surgery
|July 3, 1999
PubMed
Summary

Marfan syndrome patients face premature death from aortic dissection. Elective aortic root replacement surgery is crucial for preventing dissection and improving long-term survival in these patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The importance of intraoperative transoesophageal monitoring when operating on renal cancers that involve the right atrium.

Annals of the Royal College of Surgeons of England·2014
Same author

Risk factors for mediastinitis following cardiac surgery: the importance of managing obesity.

The Journal of hospital infection·2014
Same author

Management of coexisting coarctation of the aorta and oesophageal atresia.

Pediatric surgery international·2013
Same author

Chest injuries in a district general hospital.

Annals of the Royal College of Surgeons of England·2009
Same author

Resolution of central sleep apnoea following implantation of a left ventricular assist device.

International journal of cardiology·2008
Same author

Heart failure surgery: a speciality in itself.

Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society·2007

Area of Science:

  • Cardiovascular Medicine
  • Genetics
  • Biomedical Engineering

Background:

  • Aortic dissection is a leading cause of premature death in Marfan syndrome.
  • Elective surgery on the aortic root can prevent aortic dissection.

Purpose of the Study:

  • To examine the mechanisms of aortic dissection in Marfan syndrome.
  • To discuss surgical interventions for aortic dissection.

Main Methods:

  • Review of genetic, structural, and pathophysiological mechanisms.
  • Discussion of surgical techniques for aortic dissection.

Main Results:

  • Fibrillin abnormalities disrupt mechanotransduction between blood flow and endothelial cells.
  • Reduced arterial distensibility increases aortic wall stress, leading to dissection.
  • Post-dissection treatment requires radical surgery and lifelong beta-blockade.

Conclusions:

  • Comprehensive lifelong medical and surgical management can extend life in Marfan syndrome.
  • Elective aortic root replacement is essential for preventing aortic dissection and distal aortic issues.

Related Experiment Videos