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Updated: Aug 12, 2026

Bovine Ovarian Cortex Tissue Culture
Published on: January 14, 2021
Severe virilization in a girl with a steroid cell tumor of the ovary
1Department of Pediatrics, Oregon Health Sciences University, Portland 97210, USA.
Abstract:
We report a 6-year-old girl with striking signs of virilization, as well as elevated concentrations of testosterone and 17-hydroxyprogesterone. Although the elevated 17-hydroxyprogesterone concentration initially suggested late-onset 21-hydroxylase deficiency, she was found to have an ovarian mass by sonography which at surgery proved to be a hilus cell subtype of steroid cell tumor. This intra-ovarian tumor appears to be the smallest tumor of its type ever reported. The testosterone concentration was normal three days after tumor resection and has remained so two years later.
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