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Related Experiment Videos

Behavioral, neuroendocrine and serotonergic consequences of single social defeat and repeated fluoxetine pretreatment

O Berton1, M Durand, S Aguerre

  • 1Neurogénétique et Stress, INSERM U471-INRA, Institut François Magendie, Bordeaux, France.

Neuroscience
|July 7, 1999
PubMed
Summary

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A single social defeat in rats caused anxiety and altered stress hormone responses. Fluoxetine pretreatment mitigated these behavioral effects and normalized stress hormone responses without impacting central serotonin systems.

Area of Science:

  • Neuroscience
  • Behavioral Science
  • Endocrinology

Background:

  • Social defeat stress is a significant factor in developing anxiety disorders.
  • Lewis rats are highly sensitive to chronic social stressors, making them a suitable model.
  • The serotonergic system plays a crucial role in stress response and mood regulation.

Purpose of the Study:

  • To analyze the behavioral, neuroendocrine, and serotonergic effects of acute social defeat in Lewis rats.
  • To investigate the impact of selective serotonin reuptake inhibitor (SSRI) fluoxetine pretreatment on these effects.
  • To model aspects of human anxiety disorders using this social defeat paradigm.

Main Methods:

  • Administered a single social defeat stressor to Lewis rats.
  • Assessed behavioral changes (anxiety, hypophagia, weight loss) and neuroendocrine responses (ACTH, corticosterone, renin).

Related Experiment Videos

  • Measured serotonergic indices including transporter density, receptor density, and synthesis/metabolism, with and without fluoxetine pretreatment.

    • Main Results:

    • Social defeat induced hypophagia, weight loss, and anxiety, with altered corticosterone, ACTH, and renin responses to stress.
    • Hippocampal serotonin transporter density decreased post-defeat, but receptor densities and synthesis were unaffected.
    • Fluoxetine pretreatment ameliorated behavioral deficits and normalized stress hormone responses, with minimal impact on central serotonergic markers.

    Conclusions:

    • A single social defeat in Lewis rats elicits behavioral and endocrine changes relevant to human anxiety.
    • Fluoxetine demonstrates adaptive behavioral and neuroendocrine effects in this model.
    • These adaptive effects occur without significant alteration of the analyzed central serotonergic system components.