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Early gastric cancer in the young: clinicopathological study
T Yokota1, N Takahashi, S Teshima
1Department of Surgery, Sendai National Hospital, Japan. yo40@sh.comminet.or.jp
Insights
Early gastric cancer (EGC) in patients under 50 presents distinct features, including diffuse type and infiltrative growth. However, the prognosis for younger patients with EGC is similar to that of older individuals.
Area of Science:
- Gastroenterology
- Oncology
- Pathology
Background:
- Reviewed 34 cases of early gastric carcinoma in patients under 50 years old (1985-1995).
- These cases represented 3.7% of all gastric cancer cases treated during the period.
- Compared data with 194 patients aged 50 and above.
Purpose of the Study:
- To analyze the characteristics of early gastric cancer in younger patients.
- To compare the features and prognosis of early gastric cancer in patients under 50 with those 50 and older.
Main Methods:
- Retrospective review of early gastric carcinoma cases.
- Comparative analysis of patient demographics, tumor location, macroscopic appearance, depth of invasion, histological type, and growth patterns.
- Statistical comparison between younger (<50) and older (≥50) patient groups.
Main Results:
- Incidence of gastric cancer was similar between genders in both age groups.
- Tumors in younger patients showed a distal location preference.
- Depressed lesions were more frequent in younger patients.
- Significant differences were noted in invasion depth, histological type, and growth patterns.
Conclusions:
- Distinctive histological features of early gastric cancer in younger patients include diffuse type with infiltrative mucosal tumors.
- The prognosis for younger patients with early gastric cancer is comparable to that of older patients.
Background:
Thirty-four cases of early gastric carcinoma in patients under 50 years of age treated in the period from 1985 to 1995 were reviewed.
Methods:
These constituted 3.7% of 923 cases of gastric cancer in patients of all ages that were treated at Sendai National Hospital during the same 10-year period. Data were compared with those of 194 patients 50 years of age or older.
Results:
The incidence of gastric cancer in men and women was almost the same in both groups. Tumours tended to be located distally in the stomach. Macroscopically, depressed lesions were more common in younger patients. Significant differences were observed in depth of invasion, histological type and histological growth patterns.
Conclusions:
The distinctive histological features of early gastric cancer in younger patients were a diffuse type of cancer with infiltrative tumours in the mucosal layer. The prognosis of younger patients was similar to that of older patients.