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Related Experiment Video

Updated: Jul 9, 2026

Intracranial Pharmacotherapy and Pain Assays in Rodents

Intracranial Pharmacotherapy and Pain Assays in Rodents

Published on: April 9, 2019

Opioids in pain management.

¹Pain Research, Nuffield Department of Anaesthetics, University of Oxford, The Churchill, Oxford Radcliffe Hospital, Headington, UK. henry.mcquay@pru.ox.ac.uk

Lancet (London, England)

|July 7, 1999

Summary

Opioid analgesics are powerful pain relievers, but their optimal use is hindered by societal factors and insufficient knowledge. Addressing these issues is crucial for effective pain management, especially in chronic and cancer pain patients.

Area of Science:

Pain Management
Pharmacology
Public Health Policy

Background:

Opioids are potent analgesics with a long history of use.
Societal factors, including historical prejudice and political influences, have impacted opioid prescribing practices.
Restrictions on opioid availability persist globally, affecting patient access to pain relief.

Purpose of the Study:

To review the current state of opioid prescribing for pain management.
To highlight the challenges and barriers to optimal opioid use.
To emphasize the importance of informed prescribing and legislation for chronic and cancer pain.

Main Methods:

Literature review focusing on opioid use in chronic and cancer pain.
Analysis of historical and contemporary factors influencing opioid prescribing.

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Discussion of the impact of policy and societal attitudes on pain management.

Main Results:

Opioid prescribing is often suboptimal due to political and societal factors, not just clinical considerations.
Historical precedents demonstrate how non-medical arguments have influenced drug regulation.
Current restrictions may lead to prolonged and unnecessary suffering for patients with chronic pain.

Conclusions:

Optimizing opioid prescribing requires addressing political, societal, and educational barriers.
Informed legislation and practice are essential to prevent undue suffering in patients with chronic and cancer pain.
Further research and open discussion are needed to ensure effective pain management with opioids.