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Peripheral endothelial dysfunction in normal pressure glaucoma.

E Henry1, D E Newby, D J Webb

  • 1Princess Alexandra Eye Pavilion, Edinburgh.

Investigative Ophthalmology & Visual Science
|July 7, 1999
PubMed
Summary
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Patients with normal pressure glaucoma exhibit impaired endothelium-mediated vasodilation, suggesting generalized vascular endothelial dysfunction. This impacts blood flow regulation in this eye condition.

Area of Science:

  • Ophthalmology
  • Vascular Biology
  • Cardiovascular Research

Background:

  • Normal pressure glaucoma (NPG) is a form of glaucoma where intraocular pressure is not elevated.
  • Vascular endothelial function plays a critical role in regulating blood flow and may be implicated in glaucoma pathogenesis.

Purpose of the Study:

  • To investigate vascular endothelial function in patients with normal pressure glaucoma.
  • To assess forearm blood flow responses to vasoactive agents in NPG patients compared to healthy controls.

Main Methods:

  • Eight NPG patients and eight healthy controls underwent forearm blood flow measurement using venous occlusion plethysmography.
  • Responses to intra-arterial infusions of sodium nitroprusside (endothelial-independent), acetylcholine (endothelial-dependent), and N(G)-monomethyl-L-arginine (nitric oxide synthase inhibitor) were assessed.

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Main Results:

  • Both groups showed dose-related forearm vasodilation with sodium nitroprusside.
  • Acetylcholine-induced vasodilation was significantly reduced in NPG patients (P=0.04).
  • Vasoconstriction induced by N(G)-monomethyl-L-arginine was similar between groups (P=0.76).

Conclusions:

  • Normal pressure glaucoma is associated with impaired peripheral endothelium-mediated vasodilation.
  • Findings suggest a generalized vascular endothelial dysfunction in patients with normal pressure glaucoma.