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Multiple fixed drug eruption caused by iomeprol (Iomeron), a nonionic contrast medium
H Watanabe1, H Sueki, T Nakada
1Department of Dermatology, Showa University School of Medicine, Tokyo, Japan.
Dermatology (Basel, Switzerland)
|July 7, 1999
Summary
This study reports the first case of multiple fixed drug eruption (FDE) caused by iomeprol, a nonionic contrast medium (NICM). Repeated exposure to iomeprol led to recurrent and more severe skin reactions.
Area of Science:
- Radiology
- Dermatology
- Pharmacology
Background:
- Nonionic contrast media (NICM) are widely used in medical imaging.
- Adverse drug reactions to NICM, such as erythema multiforme, are documented.
- Fixed drug eruption (FDE) is a specific type of cutaneous drug reaction.
Observation:
- A 67-year-old woman developed multiple erythematous papules after iomeprol administration for a CT scan.
- The lesions evolved into plaques and recurred with increased severity upon re-exposure to iomeprol.
- Diagnostic tests, including patch and intradermal testing, confirmed iomeprol as the causative agent.
Findings:
- This is the first reported case of multiple fixed drug eruption (FDE) attributed to iomeprol, a type of NICM.
- The study demonstrates that NICM can induce FDE, not just erythema multiforme.
- Re-administration of iomeprol resulted in a more severe recurrence of the FDE.
Implications:
- Nonionic contrast media should be considered as potential triggers for fixed drug eruption.
- Clinicians should be aware of the possibility of FDE with iomeprol and other NICM.
- Further investigation into the mechanisms of NICM-induced FDE is warranted.