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Failure of gamma-interferon to decrease mortality from group B streptococcal sepsis in neonatal rats.

R R Wittler1, R W Harris, D D Paine

  • 1Department of Pediatrics, Fitzsimons Army Medical Center, Aurora, Colo., USA. rwittler@ix.netcom.com

Biology of the Neonate
|July 8, 1999
PubMed
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Penicillin alone improved survival in neonatal rats with group B streptococcal sepsis. Adding gamma-interferon (IFN-gamma) to penicillin did not significantly increase survival rates in this neonatal sepsis model.

Area of Science:

  • Neonatal immunology
  • Infectious diseases
  • Pharmacology

Background:

  • Neonates exhibit impaired immune responses, including reduced leukocyte chemotaxis and deficient gamma-interferon (IFN-gamma) production.
  • IFN-gamma plays a crucial role in enhancing neonatal leukocyte activation and mobility, suggesting a potential therapeutic target.

Purpose of the Study:

  • To evaluate the efficacy of combining IFN-gamma with penicillin in improving survival rates for group B streptococcal (GBS) sepsis in a neonatal rat model.
  • To compare the survival outcomes of rats treated with penicillin alone versus those treated with both IFN-gamma and penicillin.

Main Methods:

  • Newborn rats were infected with group B streptococci.
  • Rats were randomized into four groups: controls (serum albumin), IFN-gamma alone, penicillin alone, and IFN-gamma plus penicillin.

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  • Survival was assessed 120 hours postinfection.

    • Main Results:

    • Survival rates were: controls 5%, IFN-gamma 4%, penicillin 23%, and IFN-gamma plus penicillin 10%.
    • Statistical analysis indicated that penicillin monotherapy significantly improved survival compared to controls.
    • No statistically significant difference in survival was observed between the penicillin group and the IFN-gamma plus penicillin group.

    Conclusions:

    • Penicillin monotherapy demonstrates efficacy in improving survival from GBS sepsis in neonatal rats.
    • The addition of IFN-gamma to penicillin therapy did not provide a statistically significant survival benefit in this neonatal sepsis model.