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A controlled study for gender selection using swim-up separation.

M A Khatamee1, S R Horn, A Weseley

  • 1New York University School of Medicine, New York, N.Y., USA. frfbaby@msn.com

Gynecologic and Obstetric Investigation
|July 8, 1999
PubMed
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This study shows that a modified swim-up semen separation technique, combined with timed intrauterine insemination, significantly improves the success rate of gender selection for both male and female offspring.

Area of Science:

  • Reproductive Medicine
  • Genetics
  • Infertility Treatment

Background:

  • Gender selection is a growing area of interest in reproductive medicine.
  • Traditional methods for gender selection have varying success rates.
  • The modified swim-up technique offers a potential advancement in sperm separation for gender preselection.

Purpose of the Study:

  • To evaluate the efficacy of a modified swim-up semen separation technique for gender selection.
  • To compare the success rates of gender selection using this technique against spontaneous conception.

Main Methods:

  • A retrospective analysis compared two treatment groups (A for female, B for male offspring) using the modified swim-up technique and intrauterine insemination (IUI).
  • Control groups conceived spontaneously, with separate controls for those desiring female (A) and male (B) offspring.

Related Experiment Videos

  • Treatment involved timed IUI with specific fractions of separated semen, along with hormonal stimulation (clomiphene citrate, human chorionic gonadotropin) in treatment group A.

    • Main Results:

    • Treatment group A achieved an 86.7% success rate for female offspring (p = 0.002) compared to controls.
    • Treatment group B demonstrated an 89.2% success rate for male offspring (p = 0.0002) compared to controls.
    • The modified swim-up technique resulted in statistically significant gender preselection outcomes.

    Conclusions:

    • The modified swim-up semen separation method, when used with additional monitoring and timed intrauterine insemination, is a statistically significant method for gender preselection.
    • This technique offers a viable option for couples seeking to select the gender of their offspring.