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New drugs for BNCT: an experimental approach
L Weissfloch1, M Bremer, P Lemmen
1Dept. of Radiation Oncology, Klinikum rechts der Isar, Munich, Germany. Lothar.Weissfloch@LRZ.TUM.de
Abstract:
New kinds of boron-containing drugs were developed and tested in several murine tumor models. The boron-containing ether lipid B-Et-11-OMe was injected in mammary carcinoma (AT17) and osteosarcoma (OTS-64) bearing mice. Furthermore boron-substituted ferrocenium derivatives were tested. Two were excessively toxic; the third could be investigated. Boron accumulation and time-dependent biodistribution were determined using alpha-particle sensitive films and inductively coupled plasma-atomic emission pectrometry (ICP-AES) and -mass spectrometry (ICP-MS) of tumors, organs and tissues. Additionally, a new method of boron detection by NMR is in preparation.