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Related Experiment Videos

[Proton pump inhibitors in pediatrics].

C Faure1, C Pelatan, J Languepin

  • 1Service de gastroentérologie pédiatrique, hôpital Robert-Debré, Paris, France.

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|July 8, 1999
PubMed
Summary

Proton pump inhibitors (PPIs) are increasingly used for pediatric peptic disorders. While safe short-term, long-term use requires monitoring due to potential effects of prolonged acid suppression.

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Plant disease·2021

Area of Science:

  • Pediatric Gastroenterology
  • Pharmacology
  • Internal Medicine

Background:

  • Proton pump inhibitors (PPIs) are standard adult treatments for peptic disorders.
  • Pediatric use of PPIs is expanding, necessitating further research.

Purpose of the Study:

  • To review the suitability and safety of PPIs in pediatric patients.
  • To highlight the mechanism of action and contrast with H2-blockers.

Main Methods:

  • Review of pharmacokinetic and clinical data on PPI use in children.
  • Analysis of the mechanism of gastric acid inhibition.

Main Results:

  • PPIs effectively inhibit gastric acid secretion in children.
  • Short-term PPI use shows minimal risk in pediatric populations.

Conclusions:

  • Current data suggest PPIs are suitable for pediatric use.
  • Long-term PPI tolerance in children needs careful monitoring due to potential consequences of acid suppression.

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