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Related Experiment Videos

Leukemia in infants.

C A Felix1, B J Lange

  • 1Division of Oncology, Children's Hospital of Philadelphia, Pennsylvania 19104-4318, USA. felix@email.chop.edu

The Oncologist
|July 8, 1999
PubMed
Summary
This summary is machine-generated.

Infant leukemias, including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML), often involve MLL gene translocations. These genetic alterations, particularly t(4;11) in ALL, significantly impact prognosis and disease development.

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Area of Science:

  • Pediatric Oncology
  • Molecular Biology
  • Genetics

Background:

  • Infant acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) share a high frequency of MLL gene translocations at 11q23.
  • Similar MLL gene rearrangements are observed in therapies targeting DNA topoisomerase II.
  • MLL gene translocations are implicated in leukemogenesis, with numerous partner genes and poorly understood fusion protein functions.

Purpose of the Study:

  • To review infant leukemias, with a specific focus on those involving MLL gene translocations.
  • To discuss the role of MLL gene translocations in the development of infant leukemia.
  • To highlight the clinical significance of MLL gene translocations, including the adverse outcome associated with t(4;11).

Main Methods:

  • Literature review of infant leukemias.

Related Experiment Videos

  • Analysis of genetic alterations, including MLL gene translocations and Ikaros alterations.
  • Examination of myelodysplastic and myeloproliferative syndromes in infants.

    • Main Results:

    • The t(4;11) translocation is the most common in infant ALL and is associated with poor outcomes.
    • Additional genetic changes, such as Ikaros alterations, are frequently found in infant ALL.
    • MLL gene translocations are a common feature in infant leukemias, influencing disease characteristics.

    Conclusions:

    • MLL gene translocations are a critical factor in infant leukemia pathogenesis.
    • Understanding MLL fusion proteins is essential for elucidating leukemogenesis.
    • Further research into genetic alterations in infant leukemia is needed to improve treatment strategies.