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Urinary tract infection in geriatric patients
1Department of Urology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
International Journal of Antimicrobial Agents
|July 8, 1999
Summary
Elderly patients with complicated urinary tract infections (UTIs) respond to antimicrobial therapy similarly to younger patients. Underlying urological conditions, not age, significantly impact treatment outcomes in elderly UTI patients.
Area of Science:
- Urology
- Infectious Diseases
- Geriatrics
Background:
- Elderly patients with urinary tract infections (UTIs) are often presumed to have poorer outcomes with antimicrobial therapy compared to younger individuals.
- The specific factors contributing to these perceived differences in treatment efficacy remain unclear.
Purpose of the Study:
- To investigate the impact of antimicrobial therapy on elderly patients diagnosed with complicated urinary tract infections (UTIs).
- To identify factors influencing the clinical response to antibiotic treatment in a diverse adult population.
Main Methods:
- A cohort of 480 patients (aged 20-79 years) with complicated UTIs (both symptomatic and asymptomatic) were treated with one of three oral antimicrobial agents: a newer quinolone or two oral cephems.
- Multivariate logistic regression analysis was employed to assess the relationship between various patient characteristics and treatment outcomes.
Main Results:
- Clinical response to antimicrobial therapy was significantly associated with the presence of general underlying diseases and specific urinary tract conditions.
- Age, UTI symptomatic status (symptomatic vs. asymptomatic), and infection site (kidney vs. bladder) were not found to be significant predictors of treatment success.
- The study found no direct correlation between patient age and the clinical effectiveness of the antimicrobial agents used.
Conclusions:
- Antimicrobial therapy effectiveness in complicated UTIs is not directly influenced by patient age.
- Thorough urological examination to identify and manage underlying conditions is crucial for successful treatment and control of complicated UTIs, particularly in the elderly population.