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Related Experiment Videos

Hepatitis E virus -- an update.

T J Harrison1

  • 1Royal Free and University College Medical School, University College London, UK.

Liver
|July 8, 1999
PubMed
Summary
This summary is machine-generated.

Hepatitis E virus (HEV) causes a significant liver disease, particularly in pregnant women. Diagnostic tools have been developed, but effective vaccines are still needed.

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Area of Science:

  • Virology
  • Hepatology
  • Public Health

Background:

  • Hepatitis E virus (HEV) is a primary cause of enterically transmitted hepatitis.
  • HEV infection poses a significant mortality risk, especially for pregnant women during epidemics.

Purpose of the Study:

  • To summarize the current understanding of Hepatitis E virus (HEV).
  • To highlight the development of diagnostic methods and the status of vaccine research.

Main Methods:

  • Molecular cloning of the HEV genome.
  • Development of diagnostic tests like enzyme immunoassays and RT-PCR.
  • Analysis of viral genome structure and potential hosts.

Main Results:

  • Diagnostic tests for HEV antibodies and RNA are available.

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  • HEV shares characteristics with caliciviruses, possessing a positive-sense RNA genome with three open reading frames.
  • The geographical range of HEV, including its potential to infect domestic animals, may be extensive.

    • Conclusions:

    • HEV is a significant public health concern with available diagnostics but no approved vaccines.
    • Further research into HEV's epidemiology and vaccine development is warranted.