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Characterization of a novel HLA-Cw*04 variant in a Laotian family: HLA-Cw*0406
E Carbonnelle1, J C Poirier, C Fortier
1Laboratoire d'Immunologie et d'Histocompatibilité, Hôpital Saint Louis, and INSERM U396, Paris, France.
Tissue Antigens
|July 8, 1999
Abstract:
The sequence of a new HLA-Cw*04 allele has been identified in a Laotian family. This allele, designated Cw*0406, differs from Cw*0403 by a single nucleotide substitution at codon 156 (CGG-->CTG) in the alpha2 domain, leading to an amino acid change from Arginine to Leucine. Further screening by specific amplification of two ethnically different populations, i.e. French (n=150) and Lebanese (n=100), provided no case of Cw*406, suggesting that the distribution of this allele may be restricted.