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Fixed drug eruption in hands caused by omeprazole
1Department of Internal Medicine, Medical Faculty, Gaziantep University, Turkey.
Summary
This report details a rare case of fixed drug eruption, a skin reaction, that occurred in a patient treated with omeprazole. Awareness of this potential adverse effect is important for clinicians.
Area of Science:
- Gastroenterology
- Dermatology
- Pharmacology
Background:
- Omeprazole is a widely used proton pump inhibitor for gastric acid suppression.
- It is generally well-tolerated, with serious adverse reactions being uncommon.
- Gastroesophageal reflux disease (GERD) is a common indication for omeprazole therapy.
Observation:
- A 37-year-old female patient presented with symptoms of epigastric pain and heartburn.
- Reflux esophagitis was diagnosed via upper gastrointestinal endoscopy.
- The patient was prescribed omeprazole 20 mg twice daily.
Findings:
- On the fourth day of omeprazole treatment, the patient developed dark-red lesions on her hands.
- These lesions were clinically identified as a fixed drug eruption.
- The eruption recurred upon rechallenge with omeprazole, confirming the drug as the causative agent.
Implications:
- This case represents the first documented instance of fixed drug eruption associated with omeprazole.
- Clinicians should consider fixed drug eruption as a potential adverse reaction to omeprazole.
- Increased awareness may improve diagnosis and management of omeprazole-induced cutaneous reactions.