Inhibitory effect of Epstein-Barr virus activation by Citrus fruits, a cancer chemopreventor
Related Experiment Video
Updated: Jul 31, 2026

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
Published on: May 27, 2011
Y Iwase1, Y Takemura, M Ju-ichi
1Faculty of Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Hyogo, Japan.
Abstract:
To search useful compounds in Citrus fruit for cancer chemoprevention, we carried out a primary screening of extracts of fruit peels and seeds from 78 species of the genus Citrus and those from two Fortunella and one Poncirus species, which were closely related to the genus Citrus. These Citrus extracts inhibited the Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol 13-acetate (TPA) as a useful screening method for anti-tumor promoters. Our results indicated that Citrus containing substances may be inhibit susceptibility factors involved in the events leading to the development of cancer.
Related Concept Videos
Mitogens and the Cell Cycle
Mechanisms of Retrovirus-induced Cancers
Cancer Prevention
Some...
Inhibition of CDK Activity
Mechanisms of Retrovirus-induced Cancers
Cancer Prevention
Some...

