Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

hnRNP complexes: composition, structure, and function.

A M Krecic1, M S Swanson

  • 1Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, IL 60611, USA.

Current Opinion in Cell Biology
|July 8, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Semi-automated segmentation to assess the lateral meniscus in normal and osteoarthritic knees.

Osteoarthritis and cartilage·2009
Same author

Developmental toxicity and genotoxicity studies of 1,1,1,3,3,3-hexachloropropane (HCC-230fa) in rats.

Toxicological sciences : an official journal of the Society of Toxicology·2003
Same author

The effect of reading ability and response formats on patients' abilities to respond to a patient satisfaction scale.

Journal of continuing education in nursing·2002
Same author

Muscleblind localizes to nuclear foci of aberrant RNA in myotonic dystrophy types 1 and 2.

Human molecular genetics·2001
Same author

Identification of an autoimmune serum containing antibodies against the Barr body.

Proceedings of the National Academy of Sciences of the United States of America·2001
Same author

Subchronic inhalation toxicity of the chlorinated propane 1,1,1,3,3,3-hexachloropropane (HCC-230fa).

Toxicological sciences : an official journal of the Society of Toxicology·2001

Heterogeneous nuclear ribonucleoproteins (hnRNPs) are key RNA-binding proteins involved in numerous cellular processes. Their unique characteristics enable diverse regulatory roles in both nuclear and cytoplasmic functions.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • Heterogeneous nuclear ribonucleoproteins (hnRNPs) are primarily nuclear proteins.
  • They bind to RNA polymerase II transcripts, forming ribonucleoprotein complexes.
  • hnRNPs participate in a wide range of cellular activities.

Purpose of the Study:

  • To summarize the multifaceted roles of hnRNPs.
  • To highlight the fundamental characteristics that enable their diverse functions.
  • To underscore their importance in multiple regulatory pathways.

Main Methods:

  • Literature review of recent studies on hnRNPs.
  • Analysis of hnRNP functions across different cellular compartments.
  • Identification of key protein characteristics driving regulatory involvement.

Related Experiment Videos

Main Results:

  • hnRNPs are involved in transcription and pre-mRNA processing.
  • They also play critical roles in cytoplasmic mRNA translation and turnover.
  • Specific hnRNP characteristics underpin their involvement in various regulatory pathways.

Conclusions:

  • hnRNPs are essential regulators with diverse functions.
  • Their fundamental properties allow for broad cellular participation.
  • Understanding hnRNPs is crucial for deciphering complex cellular regulation.