Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Large-scale chromatin structure and function.

A S Belmont1, S Dietzel, A C Nye

  • 1Department of Cell and Structural Biology, University of Illinois, Urbana-Champaign, B107 CLSL, 601 South Goodwin Avenue, Urbana, IL 61801, USA. asbel@uiuc.edu

Current Opinion in Cell Biology
|July 8, 1999
PubMed
Summary

New findings reveal higher levels of chromatin folding in living cells, impacting gene expression. This large-scale organization of the 30 nm fiber within interphase chromosomes is crucial for cellular function.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Resolution of spatial constraints during replication of peripheral chromatin].

Tsitologiia·2015
Same author

Insights into interphase large-scale chromatin structure from analysis of engineered chromosome regions.

Cold Spring Harbor symposia on quantitative biology·2011
Same author

Mitotic chromosome structure: reproducibility of folding and symmetry between sister chromatids.

Biophysical journal·2009
Same author

DNA-repair protein distribution along the tracks of energetic ions.

Radiation protection dosimetry·2006
Same author

Microirradiation of cells with energetic heavy ions.

Radiation and environmental biophysics·2004
Same author

BRCA1-induced large-scale chromatin unfolding and allele-specific effects of cancer-predisposing mutations.

The Journal of cell biology·2001

Area of Science:

  • Molecular Biology
  • Genetics
  • Cell Biology

Background:

  • The structure of chromatin, the complex of DNA and proteins that forms chromosomes, is crucial for genome function.
  • While the 30 nm fiber is a known level of chromatin organization, higher-order structures in living cells remained less understood.

Purpose of the Study:

  • To discuss the functional implications of newly established higher-order chromatin folding levels.
  • To explore the role of large-scale chromatin organization in regulating gene expression.

Main Methods:

  • Analysis of recent experimental results from studies conducted in living cells.
  • Review and synthesis of data pertaining to chromatin folding above the 30 nm fiber.

Main Results:

Related Experiment Videos

  • Evidence now confirms the existence of chromatin folding levels beyond the 30 nm fiber in interphase chromosomes.
  • These higher-order structures are present within living cells.

Conclusions:

  • Large-scale chromatin organization plays a significant role in cellular processes.
  • This organization, including structures above the 30 nm fiber, is likely involved in the regulation of gene expression.