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V(D)J recombination: on the cutting edge
1Department of Molecular Biology, Massachusetts General Hospital, 50 Blossom Street, Boston, MA 02114, USA.
The vertebrate immune system has evolved an elegant mechanism for generating an enormous diversity in antigen receptor binding specificity from a limited amount of genetic information. Recent advances are rapidly increasing our understanding of this unusual site-specific DNA rearrangement that assembles the antigen receptor genes during lymphoid development.
The vertebrate immune system has evolved an elegant mechanism for generating an enormous diversity in antigen receptor binding specificity from a limited amount of genetic information. Recent advances are rapidly increasing our understanding of this unusual site-specific DNA rearrangement that assembles the antigen receptor genes during lymphoid development.