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Synaptic vesicle docking and fusion.

S M Bajjalieh1

  • 1Department of Pharmacology, D-431 Health Sciences Building, Box 357280, University of Washington, Seattle, Washington 98195-7280, USA. bajjalie@u.washington.edu

Current Opinion in Neurobiology
|July 8, 1999
PubMed
Summary

Neurotransmitter secretion and constitutive membrane trafficking involve vesicle targeting and fusion through protein interactions. Specialized regulators likely enable the precise control and plasticity seen in synaptic exocytosis.

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Area of Science:

  • Cell Biology
  • Neuroscience
  • Molecular Biology

Background:

  • Neurotransmitter secretion and constitutive membrane trafficking share mechanistic similarities.
  • Both processes involve vesicle targeting to acceptor membranes and subsequent fusion.
  • Protein-protein interactions are critical for mediating these fusion events.

Purpose of the Study:

  • To elucidate the protein complexes involved in neurotransmitter secretion.
  • To define the sequential order of action for these protein complexes.
  • To understand the role of specialized regulators in synaptic exocytosis.

Main Methods:

  • Literature review of recent research on membrane trafficking and exocytosis.
  • Analysis of protein-protein interaction networks.

Related Experiment Videos

  • Comparative analysis of constitutive and regulated exocytosis pathways.

    • Main Results:

    • An expanded list of protein complexes participating in neurotransmitter secretion has been identified.
    • The temporal order of action for key protein complexes is beginning to be established.
    • Specialized regulators are implicated in the unique characteristics of synaptic exocytosis.

    Conclusions:

    • Neurotransmitter secretion is mechanistically linked to constitutive membrane trafficking.
    • The precise regulation, rapid fusion, and plasticity of synaptic exocytosis are attributed to specialized regulatory proteins.