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Updated: Aug 15, 2026

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes
09:14

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes

Published on: June 13, 2014

Cas-L is required for beta 1 integrin-mediated costimulation in human Tcells

K Kamiguchi1, K Tachibana, S Iwata

  • 1Division of Tumor Immunology, Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.

Journal of Immunology (Baltimore, Md. : 1950)
|July 8, 1999
PubMed
Summary

Cas-L, a key docking protein, is crucial for beta 1 integrin-mediated T cell costimulation. Its tyrosine phosphorylation by beta 1 integrin signaling restores impaired T cell activation in Jurkat cells.

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