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Infectious keratitis in leprosy.

D John1, E Daniel

  • 1Branch of Ophthalmology, Schieffelin Leprosy Research and Training Centre, Karigiri, Vellore District, Tamilnadu, India.

The British Journal of Ophthalmology
|July 9, 1999
PubMed
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Leprosy patients, particularly males with lepromatous leprosy, frequently develop corneal ulcers, often with poor visual outcomes. Reduced corneal sensation and lagophthalmos are key risk factors for these fungal infections.

Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Dermatology

Background:

  • Leprosy, a chronic infectious disease, can lead to significant ocular complications.
  • Corneal ulcers are a serious manifestation, potentially causing vision loss in leprosy patients.

Purpose of the Study:

  • To characterize leprosy patients with corneal ulcers.
  • To identify ocular features associated with these ulcers.
  • To determine the causative organisms of infective corneal ulcers in this population.

Main Methods:

  • Retrospective review of leprosy patients treated for corneal ulcers between 1992 and 1997.
  • Analysis of patient demographics, leprosy type, ocular findings, and microbial cultures.

Main Results:

Related Experiment Videos

  • Corneal ulcers were more prevalent in males and those with lepromatous leprosy.
  • Associated ocular conditions included decreased corneal sensation (39 eyes), lagophthalmos (34 eyes), and hand deformities (43 patients).
  • Fungal pathogens were identified in a significant proportion of ulcers, with poor visual improvement post-treatment (18%).

Conclusions:

  • Leprosy-associated corneal ulcers disproportionately affect males and lepromatous leprosy patients.
  • Decreased corneal sensation, lagophthalmos, and hand deformities are strongly linked to ulcer development.
  • Fungal infections are common causes of corneal ulcers in leprosy, often presenting late with unfavorable visual prognoses.