Dependence of cardiac strength-interval curves on pacing rate

The purpose of the research is to determine how the pacing rate affects the strength-interval curve in cardiac tissue. Computer simulations are used to calculate the cathodal and anodal strength-interval curves. The tissue is represented by the bidomain model with Beeler-Reuter membrane properties. The strength-interval curves shift to shorter intervals as the pacing rate increases. However, the shape of the strength-interval curve, including the separation into 'make' and 'break' sections and the presence of a 'dip', is insensitive to pacing rate.