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[Metastatic brain tumors].

G L Taddei1, D Moncini, M R Raspollini

  • 1Istituto di Anatomia e Istologia Patologica, Università degli Studi di Firenze. taddei_gl@cesit1.unifi.it

Pathologica
|July 9, 1999
PubMed
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This study analyzed 211 brain metastases surgeries, finding lung tumors and breast cancer most common. Survival averaged 14 months, with renal carcinoma showing a better prognosis than melanoma.

Area of Science:

  • Neurosurgery
  • Oncology
  • Pathology

Background:

  • Brain metastases represent a significant challenge in cancer care.
  • Surgical intervention is a key treatment modality for selected patients.
  • Understanding the primary sources and prognostic factors is crucial for patient management.

Purpose of the Study:

  • To analyze the characteristics and outcomes of patients undergoing surgery for brain metastases.
  • To identify the primary tumor types leading to brain metastases.
  • To evaluate prognostic factors influencing survival after surgical treatment.

Main Methods:

  • Retrospective review of 211 surgical cases of brain metastases.
  • Data collected from the Department of Pathology, University of Florence (1980-1995).

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  • Analysis of patient demographics, primary tumor origins, survival rates, and recurrence patterns.

    • Main Results:

    • Lung tumors (47%) and breast cancer (9%) were the most frequent primary sources.
    • Average survival was 14 months; 4% survived over 5 years.
    • Recurrence occurred in 17% of patients, with an average survival of 11 months post-relapse.
    • Renal carcinoma (27 months) had a favorable prognosis, while metastatic melanoma (7 months) had a poor prognosis.

    Conclusions:

    • Surgical management of brain metastases is associated with a median survival of 14 months.
    • Primary tumor type significantly impacts prognosis, with renal carcinoma favorable and melanoma unfavorable.
    • Further research into optimizing treatment strategies for different metastatic origins is warranted.