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Related Experiment Videos

Why do preterm infants die in the 1990s?

L W Doyle1, S Rogerson, S L Chuang

  • 1Division of Paediatrics, Royal Women's Hospital, Melbourne, VIC. l.doyle@obgyn-rwh.unimelb.edu.au

The Medical Journal of Australia
|July 9, 1999
PubMed
Summary

Mortality rates for preterm infants significantly decrease with gestational age, especially between 23 and 28 weeks. Lethal congenital anomalies were the primary cause of death, with few preventable causes identified in this study.

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Area of Science:

  • Neonatalogy
  • Perinatology
  • Pediatric Mortality Studies

Background:

  • Preterm birth (23-36 weeks' gestational age) presents significant mortality risks.
  • Understanding mortality rates and causes is crucial for improving neonatal care.
  • Lethal congenital anomalies are a major factor in preterm infant mortality.

Purpose of the Study:

  • To determine the mortality rate for preterm infants (23-36 weeks' gestational age).
  • To identify the causes of death in preterm infants, with a focus on avoidable factors.
  • To analyze the relationship between gestational age and mortality risk.

Main Methods:

  • Prospective cohort study conducted at a tertiary referral hospital.
  • Inclusion of 2475 consecutive liveborn infants with gestational ages from 23 to 36 weeks.

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  • Data collection on mortality rates and causes of death during primary hospitalization.

    • Main Results:

    • Overall mortality rate was 4.8% (118/2475).
    • Mortality decreased sharply from 64.5% at 23 weeks to 4.0% at 28 weeks, then slowed.
    • Lethal congenital anomalies accounted for 50 deaths and were the leading cause, particularly in infants born after 28 weeks.

    Conclusions:

    • Mortality rates for preterm infants decline rapidly between 23 and 28 weeks' gestational age.
    • Survival rates for preterm infants born after 31 weeks approach those of term infants.
    • Lethal congenital anomalies are the primary cause of death, while preventable causes are infrequent.