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Related Experiment Videos

Clinicopathological study on liver dysfunction in measles.

A Satoh1, H Kobayashi, T Yoshida

  • 1Second Department of Internal Medicine, Aichi Medical University, Aichi-gun.

Internal Medicine (Tokyo, Japan)
|July 9, 1999
PubMed
Summary

Measles can cause liver dysfunction, indicated by elevated liver enzymes like AST and ALT, without causing jaundice. Measles virus RNA detected in liver biopsies suggests direct viral impact on liver cells.

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Area of Science:

  • Hepatology
  • Virology
  • Pediatrics

Background:

  • Measles is a highly contagious viral illness.
  • Liver dysfunction is a potential complication of measles.
  • The direct role of measles virus in liver injury is not fully understood.

Purpose of the Study:

  • To investigate the clinical presentation and liver involvement in measles patients.
  • To determine the direct effect of measles virus on liver cells.

Main Methods:

  • Analysis of clinical data from eight measles patients with liver dysfunction.
  • Biochemical assessment of liver enzymes (AST, ALT, LDH).
  • Percutaneous liver biopsy with histological and electron microscopy examination.
  • Detection of measles virus RNA using RT-PCR.

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Main Results:

  • All patients exhibited elevated AST, ALT, and LDH levels, but no jaundice.
  • Liver enzyme levels normalized approximately three weeks post-rash onset.
  • Liver biopsies showed minimal hepatocellular necrosis without significant portal inflammation.
  • Measles virus RNA was detected in liver tissue, while virus particles were not observed via electron microscopy.

Conclusions:

  • Measles virus directly impacts liver cells, leading to transient liver dysfunction.
  • Elevated liver enzymes in measles are indicative of direct viral hepatitis.
  • Further research is warranted to explore the mechanisms of measles-induced liver injury.