Related Experiment Video
Updated: Sep 6, 2026

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice
Published on: June 12, 2021
Control of tumor development by intratumoral cytokines
F Pages1, V Vives, C Sautès-Fridman
1INSERM U255, Institut Curie, Paris, France.
Abstract:
The local immune reactions may influence the clinical outcome of human tumors. In carcinoma of the cervix, high gene expression of IL6 with tumor invasiveness whereas lack of gene expression of IFNbeta is correlated with poor prognosis. In colorectal cancer, lack of expression of IFNbeta is associated with the presence of distant metastasis and poor survival. The production of IL17 and IL18, inducers of IL6 and IFNbeta respectively is regulated in these tumors and may control the levels of the effector cytokines, i.e. IL6 and IFNbeta. The mechanisms by which these cytokines act are linked to the recruitment of effector cells such as macrophages.
Related Concept Videos
Cancer
Inhibition of Cdk Activity
The Tumor Microenvironment
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
Tumor Immunotherapy

