Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Thrombin inhibitors based on [5,5] trans-fused indane lactams.

M Pass1, S Abu-Rabie, A Baxter

  • 1Glaxo Wellcome Research and Development, Stevenage, Herts, United Kingdom. mp8073@glaxowellcome.co.uk

Bioorganic & Medicinal Chemistry Letters
|July 9, 1999
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Is it justified to order an upfront cytomegalovirus immunohistochemical stain in patients with severe inflammatory bowel disease and ulceration?

Human pathology·2026
Same author

Photosynthetic characteristics of upland cotton (<i>Gossypium hirsutum</i>) recessive genic male sterile line YA-1 with virescent trait.

Photosynthetica·2025
Same author

Archean rifts and triple-junctions revealed by gravity modeling of the southern Superior Craton.

Nature communications·2025
Same author

Estimating population mental health effects of the rollout of Universal Credit in the UK using standard and novel Difference-in-Differences analysis, 2009-2019.

Public health·2025
Same author

Nuclear Recoil Calibration at Sub-keV Energies in LUX and Its Impact on Dark Matter Search Sensitivity.

Physical review letters·2025
Same author

Diagnostic accuracy of prenatal ultrasound in coarctation of aorta: systematic review and individual participant data meta-analysis.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2024

Researchers synthesized novel trans-fused lactams with an indane core. Compound 19 demonstrated improved plasma stability and significant in vitro anticoagulant effects, outperforming its lactone analog.

Area of Science:

  • Medicinal Chemistry
  • Organic Synthesis
  • Pharmacology

Background:

  • Lactam and lactone structures are common in biologically active molecules.
  • Indane derivatives have shown diverse pharmacological properties.
  • Developing stable anticoagulant agents remains a significant therapeutic challenge.

Purpose of the Study:

  • To synthesize and characterize novel trans-fused lactam compounds incorporating the indane nucleus.
  • To evaluate the plasma stability and in vitro anticoagulant activity of these novel lactams.
  • To compare the properties of the synthesized lactams with their corresponding lactone analogs.

Main Methods:

  • Multi-step organic synthesis to prepare a series of trans-fused lactams.
  • Characterization of synthesized compounds using spectroscopic techniques.

Related Experiment Videos

  • In vitro assays to assess plasma stability and anticoagulant activity (e.g., Prothrombin Time, Activated Partial Thromboplastin Time).

    • Main Results:

    • Successful synthesis of a series of trans-fused lactams containing the indane moiety.
    • Compound 19 exhibited significantly enhanced plasma stability compared to its lactone counterpart.
    • Compound 19 demonstrated appreciable in vitro anticoagulant activity.

    Conclusions:

    • Trans-fused lactams based on the indane nucleus represent a promising class of compounds.
    • The enhanced plasma stability of Compound 19 suggests potential for improved pharmacokinetic profiles.
    • These findings warrant further investigation into the therapeutic potential of these novel lactam derivatives as anticoagulants.