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Synthesis and evaluation of 1-position-modified inositol 1,4,5-trisphosphate analogs
1Graduate School of Pharmaceutical Science, The University of Tokyo, Department of Pharmacology, Japan.
Bioorganic & Medicinal Chemistry Letters
|July 9, 1999
Abstract:
IP3 analogs were synthesized by the modification of phosphate at the 1-position, and their affinity for the IP3 receptor was analyzed by means of surface plasmon resonance measurements. Our results suggest that a hydrophobic and charged moiety linked to this position enhances the affinity for the IP3 receptor.