Related Experiment Video
Updated: Oct 19, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
Cyclodextrins as diethylstilbestrol carrier system: characterization of diethylstilbestrol-cyclodextrins complexes
E Núñez-Delicado1, M Sojo, A Sánchez-Ferrer
1Department of Biochemistry and Molecular Biology-A, Faculty of Biology, University of Murcia, Spain.
Purpose:
The in vitro formation of DES-cyclodextrins inclusion complexes was characterized using lipoxygenase as enzymatic system.
Methods:
DES-cyclodextrins complexes were obtained in aqueous solution.
Results:
The addition of cyclodextrins to the reaction medium had an inhibitory effect on DES oxidation by lipoxygenase due to the drug's complexation into the cyclodextrin cavity. This inhibitory effect depends on the complexation constant between DES and the cyclodextrins type used. In this case, beta-, 2-hydroxypropyl-beta- and gamma-cyclodextrins have similar complexation constants and therefore produce the same inhibitory effect. Moreover, depending on the type of cyclodextrins used, the solubility of DES can be enhanced up to 956 times, while the lipoxygenase activity remains constant.
Conclusions:
These results suggest that the system described may be used as a controlled-release delivery system for DES, since it may diminish the local and systemic adverse side effects caused by high concentrations of the drug.
Related Concept Videos
Stability of Conjugated Dienes
A comparison of the enthalpies of hydrogenation of dienes reveals that conjugated dienes release less heat on hydrogenation, rendering them more stable than their nonconjugated analogs.
Intramolecular Claisen Condensation of Dicarboxylic Esters: Dieckmann Cyclization
Intrauterine Drug Delivery Systems
Stability of Substituted Cyclohexanes
The two chair conformations of cyclohexanes undergo rapid interconversion at room temperature. Both forms have identical energies and stabilities, each comprising equal amounts of the equilibrium mixture. Replacing a hydrogen atom with a functional group makes the two conformations energetically non-equivalent.
For example, in...
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
Diels–Alder Reaction Forming Bridged Bicyclic Products: Stereochemistry
