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The transition from hyperplasia to invasive carcinoma of the breast
1Department of Histopathology, University College London Medical School, U.K. s.lakhani@ucl.ac.uk
The Journal of Pathology
|July 9, 1999
Abstract:
The multistep model of carcinogenesis in the breast suggests a transition from normal epithelium to invasive carcinoma via non-atypical and atypical hyperplasia and in situ carcinoma. Within the breast, these proliferations are heterogeneous in their cytological and architectural characteristics. This review considers the evidence supporting a precursor role for these preinvasive lesions.