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Paraneoplastic painful ulnar neuropathy
M K Sharief1, S F Robinson, D A Ingram
1Department of Neurology, Guy's, King's and St. Thomas's Medical School, Guy's Hospital, London SE1 9RT, U.K.
Muscle & Nerve
|July 9, 1999
Abstract:
A 58-year-old woman developed painful, bilateral ulnar neuropathy in conjunction with small cell lung carcinoma and high serum titer of anti-Hu antibody. An incidental stage I plasma cell dyscrasia, with immunoglobulin G kappa monoclonal protein, was also present. Electropysiological assessment excluded a generalized neuropathy, and nerve biopsy showed marked loss of myelinated and small unmyelinated fibers, without inflammatory changes or amyloid deposition. High titers of circulating anti-Hu antibody can be associated with symptoms resembling a paraneoplastic mononeuropathy.