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X-linked mental retardation associated with cleft lip/palate maps to Xp11.3-q21.3
L E Siderius1, B C Hamel, H van Bokhoven
1Clinical Genetics Center Utrecht, Utrecht, The Netherlands.
American Journal of Medical Genetics
|July 9, 1999
Abstract:
A family is described in which X-linked mild to borderline mental retardation (MR) is associated with cleft lip/palate. Linkage analysis showed a maximum LOD score of Z=2.78 at straight theta=0.0 for the DXS441 locus with flanking markers DXS337 and DXS990, defining the region Xp11.3-q21.3 with a linkage interval of 25 cM.