Fast lipid-suppressed MR temperature mapping with echo-shifted gradient-echo imaging and spectral-spatial excitation

The water proton resonance frequency (PRF) is temperature dependent and can thus be used for magnetic resonance (MR) thermometry. Since lipid proton resonance frequencies do not depend on temperature, fat suppression is essential for PRF-based temperature mapping. The efficacy of echo-shifted (TE > TR) gradient-echo imaging with spectral-spatial excitation is demonstrated, resulting in accurate and rapid, lipid-suppressed, MR thermometry. The method was validated on phantoms, fatty duck liver, and rat thigh, demonstrating improvements in both the speed and precision of temperature mapping. Heating of a rat thigh with focused ultrasound was monitored in vivo with an accuracy of 0.37 degree C and a time resolution of 438 msec.