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Morphogenesis of the vertebrate limb.

L Wolpert, J Lewis, D Summerbell

    Ciba Foundation Symposium
    |January 1, 1975
    PubMed
    Summary

    Limb development and regeneration involve cells acquiring positional values. A

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    Area of Science:

    • Developmental Biology
    • Regenerative Medicine
    • Cellular Biology

    Background:

    • Pattern formation in vertebrate limb development and regeneration is a complex process.
    • Understanding how cells acquire specific positional values is key to controlling tissue differentiation.

    Purpose of the Study:

    • To propose a model for how positional values are established in the developing vertebrate limb.
    • To explain the roles of the progress zone and organizing region in pattern formation.
    • To discuss the relevance of this model to amphibian limb regeneration.

    Main Methods:

    • Theoretical modeling of limb development.
    • Analysis of positional signaling and cell differentiation.
    • Review of existing literature on limb regeneration.

    Main Results:

    • The proximodistal positional value is established by changes within a 'progress zone' at the limb bud tip.
    • The anteroposterior positional value is determined by a signal from an organizing region, with only progress zone cells responding.
    • Skeletal element lengths are specified shortly after cells leave the progress zone and show limited regulation.

    Conclusions:

    • The progress zone model provides a framework for understanding vertebrate limb pattern formation.
    • Positional values assigned in the progress zone dictate cell differentiation and subsequent growth.
    • The model has implications for understanding and potentially enhancing amphibian limb regeneration.

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