Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

[Endothelial function and the microcirculation in diabetes mellitus].

E Arosio¹, P Minuz, M Prior

¹Cattedra di Terapia Medica, Università degli Studi di Verona.

Annali Italiani Di Medicina Interna : Organo Ufficiale Della Societa Italiana Di Medicina Interna

|July 10, 1999

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Cultural and Linguistic Adaptation and Validation of a Nutrition Literacy Instrument for Use in People With Cancer in the United Kingdom.

Journal of human nutrition and dietetics : the official journal of the British Dietetic Association·2026

Same author

Healthcare professionals' knowledge, understanding and confidence to manage chronic pain after cancer treatment: A UK survey.

European journal of oncology nursing : the official journal of European Oncology Nursing Society·2024

Same author

High rate of pulmonary thromboembolism in patients with SARS-CoV-2 pneumonia.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2020

Same author

Abnormal ankle-brachial index (ABI) predicts primary and secondary cardiovascular risk and cancer mortality.

European journal of internal medicine·2020

Same author

Research priority setting in women's health: a systematic review.

BJOG : an international journal of obstetrics and gynaecology·2020

Same author

Predicting acoustic dose associated with marine mammal behavioural responses to sound as detected with fixed acoustic recorders and satellite tags.

The Journal of the Acoustical Society of America·2019

Endothelial dysfunction, characterized by impaired microcirculation and vascular changes, precedes diabetic microangiopathy. Hyperglycemia and related metabolic issues are key drivers of this dysfunction.

Area of Science:

Cardiovascular Science
Endocrinology
Pathophysiology

Context:

Diabetes mellitus is a leading cause of microvascular complications.
Endothelial dysfunction plays a critical role in the development of diabetic microangiopathy.
Early detection of microcirculatory alterations is crucial for managing diabetes.

Purpose:

To review the role of endothelial dysfunction in diabetic microangiopathy.
To explore the mechanisms linking hyperglycemia to endothelial dysfunction.
To discuss the impact of atherosclerosis on diabetic microcirculation.

Summary:

Diabetic microangiopathy involves reversible microcirculatory changes (increased capillary pressure, blood flow, permeability) and irreversible structural modifications (basal membrane thickening).

Related Experiment Videos

Endothelial dysfunction, marked by reduced vasodilation and altered antithrombotic properties, precedes microvascular lesions in diabetes.

Hyperglycemia, abnormal lipoprotein metabolism, glycation end products, oxidative stress, and insulin resistance contribute to endothelial dysfunction.

Impact:

Understanding endothelial dysfunction mechanisms can lead to targeted therapies for diabetic microangiopathy.
Early identification of endothelial dysfunction may allow for interventions to prevent or delay microvascular complications.
This review highlights the intricate relationship between metabolic control and vascular health in diabetes.