Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Biochemical markers of gastric functioning].

D Basso1, A L Stefani, N Gallo

  • 1Dipartimento di Medicina di Laboratorio, Università, Padova.

Recenti Progressi in Medicina
|July 10, 1999
PubMed
Summary

Serum pepsinogen C (PGC) levels can indicate gastric inflammation, especially from H. pylori infection in the antrum. Increased PGC and polymorphonuclear (PMN) oxidative burst suggest damage, even if infection persists.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Depemokimab and the twice-yearly regimen: pharmacological implications and therapeutic positioning in severe eosinophilic respiratory diseases.

Frontiers in immunology·2026
Same author

Quantification of plasma APOE4 with a novel automated Lumipulse immunoassay enables the identification of homozygous and heterozygous APOE ε4 carrier status.

Clinica chimica acta; international journal of clinical chemistry·2025
Same author

Burnout between personality traits and bowel disorders. An exploratory study of a sample of nurses students.

La Clinica terapeutica·2025
Same author

The use of machine learning models to predict progression-free survival and overall survival outcomes from waterfall plots in randomized clinical trials (MAP-OUTCOMES).

ESMO open·2025
Same author

Seminars in epileptology: How to diagnose status epilepticus in adults and children.

Epileptic disorders : international epilepsy journal with videotape·2025
Same author

Adolescent mothers and postpartum depression: a possible connection? A Scoping review.

La Clinica terapeutica·2025

Area of Science:

  • Gastroenterology
  • Immunology
  • Microbiology

Background:

  • Gastric mucosal inflammation and atrophy can be indicated by serum pepsinogen A (PGA) and pepsinogen C (PGC) levels.
  • The gastric body produces both PGA and PGC, while the antrum produces only PGC.
  • H. pylori infection primarily affects the antrum, suggesting PGC variations are more indicative than PGA.

Purpose of the Study:

  • To investigate the relationship between H. pylori infection, serum pepsinogen levels (PGA and PGC), and gastric inflammation.
  • To assess the role of polymorphonuclear (PMN) oxidative burst as an indicator of H. pylori-induced gastric inflammation.

Main Methods:

  • Serum levels of PGA and PGC were determined.
  • The association between H. pylori infection (specifically cagA positive strains) and serum PGC levels was analyzed.

Related Experiment Videos

  • Polymorphonuclear (PMN) oxidative burst response to H. pylori extracts was measured in infected and non-infected subjects.

    • Main Results:

    • Serum PGC levels significantly increased in patients with H. pylori infection, particularly with virulent cagA positive strains.
    • Serum PGA levels showed less significant changes compared to PGC in antrum-predominant diseases.
    • Peripheral PMN oxidative burst was significantly higher in H. pylori-infected subjects compared to controls.

    Conclusions:

    • Serum PGC is a more sensitive indicator than PGA for H. pylori infection affecting the gastric antrum.
    • Increased PMN oxidative burst in H. pylori-infected individuals, while not eliminating infection, may contribute to gastric mucosal damage.
    • These findings highlight potential biomarkers for diagnosing and understanding the pathogenesis of H. pylori-associated gastritis.